Multiple Cerebral Cavernoma Associated with Biatrial Myxoma: A Case Report

A 38-year old man with a past medical history of bipolar disorder known for 8 years and treated medically. He experienced multiple episodes of right hemi facial paresis for the last 2 years which worsened in the previous year followed by ataxia, dizziness, diplopia, vomiting and loss of consciousness. an axial Transthorasic echocardiography showed large mobile biatrial masses which was resected surgically and both tumors had the histopathological feature of benign cardiac myxoma and brain CT scan without contrast showed multiple sub cortical hyperdense lesions. One year later brain MRI with gadolinium showed two large hyperintense lesions and patients underwent surgery for resection of both intracranial lesions. The masses have typical morphological features of a cavernoma and both of them reported cavernomas histopathologically without metastatic evidence. Cavernoma is a vascular hamartoma, characterized by channels which are separated from brain tissue by a thin adventitia layer. Several cavernomas have been reported in association with other mesenchymal anomalies in other organs including the retina angiomas, liver Angiosarcoma, skin angioma, liver and skin cavernoma but only three cardiac myxoma associated with cavernomas have been reported.