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Treatment with Lithium Induces a Long-Term Enhancement of Neurogenesis in the Subventricular Zone of the Ts65Dn model of Down Syndrome

Author

Listed:
  • Fiorenza Stagni
  • Andrea Giacomini
  • Marco Emili
  • Beatrice Uguagliati
  • Patrizia Bianchi
  • Renata Bartesaghi
  • Sandra Guidi

    (Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy)

Abstract

Down syndrome (DS), a genetic condition due to triplication of chromosome 21, is characterized by neurogenesis impairment in the major neurogenic niches of the brain. This defect largely accounts for brain hypotrophy and, hence, intellectual disability in DS. We previously found that treatment with lithium restored the number of proliferating cells in the subventricular zone (SVZ) and of new granule cells in the olfactory bulb (OB) of the Ts65Dn mouse model of DS, suggesting that treatment with lithium may be a potential tool for neurogenesis restoration in DS. The goal of the current study was to establish whether the positive effects of lithium on neurogenesis are retained after treatment cessation. To this aim, adult Ts65Dn mice aged 13 months were treated with lithium for one month, injected with BrdU during the last 3 days of treatment, and killed one month after treatment cessation.

Suggested Citation

  • Fiorenza Stagni & Andrea Giacomini & Marco Emili & Beatrice Uguagliati & Patrizia Bianchi & Renata Bartesaghi & Sandra Guidi, 2018. "Treatment with Lithium Induces a Long-Term Enhancement of Neurogenesis in the Subventricular Zone of the Ts65Dn model of Down Syndrome," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 7(4), pages 75-82, May.
    • Handle: RePEc:adp:joajnn:v:7:y:2018:i:4:p:75-82
    DOI: 10.19080/OAJNN.2018.07.555718
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