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Developing Clinical Guidelines to Treat Stroke with Stem Cells Part I: Acute and Sub Acute Ischemic Stroke

Author

Listed:
  • Ruiz-Navarro Francisco
  • Kobinia Georg

    (Austrian Society for Regenerative Medicine, Austria)

Abstract

The evolution of stem cell-based therapies has been exponential in recent years, going from animal models to human clinical trials in a relatively short period of time. The field has also changed the rationales about the main mechanisms of action. While stem cell-based therapies were previously thought to be just the replacement of damaged cells, more complex actions have been discovered in the meantime, including paracrine effects, activation of local stem cells towards trans differentiating, neuro protection of local tissues and a systemic and local neuro-immuno modulation. Furthermore, additional methods to repair genetic defects or improve autologous stem cells with relatively and easy techniques are revolutionizing the field. This means that we are currently experiencing how stem cell-based therapies are increasingly employed to develop curative treatments.

Suggested Citation

  • Ruiz-Navarro Francisco & Kobinia Georg, 2017. "Developing Clinical Guidelines to Treat Stroke with Stem Cells Part I: Acute and Sub Acute Ischemic Stroke," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 5(4), pages 54-70, August.
    • Handle: RePEc:adp:joajnn:v:5:y:2017:i:4:p:54-70
    DOI: 10.19080/OAJNN.2017.05.555668
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