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Primary Central Nervous System Lymphoma: A Diagnostic and Therapeutic Challenge-Case Report and Short Review

Author

Listed:
  • Adriana Octaviana Dulamea
  • Ioana Lupescu

    (UMF Carol Davila Bucharest, Romania)

  • Alina Buture

    (Department of Neurology, Fundeni Clinical Institute, Romania)

  • Sorina Badelita

    (Department of Hematology, Fundeni Clinical Institute, Romania)

  • Ioana Lupescu

    (Department of Radiology Fundeni Clinical Institute, Romania)

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare CNS tumor characterized, in immune competent patients, by solitary, homogenous lesions, usually located into the cerebral hemispheres or basal ganglia. Authors report a case of PCNSL with unusual magnetic resonance imaging (MRI) findings, resembling the lesions of acute disseminate encephalomyelitis. New advanced MR imaging techniques such as diffusion, perfusion, MRS may help to differentiate PCNSL from other CNS lesions, for the prognostic, and for treatment response monitoring. PCNSL treatment involves high dose chemotherapy including methotrexate and cytarabine combined with anti-CD20 antibody-based immunotherapy and whole brain radiotherapy

Suggested Citation

  • Adriana Octaviana Dulamea & Ioana Lupescu & Alina Buture & Sorina Badelita & Ioana Lupescu, 2017. "Primary Central Nervous System Lymphoma: A Diagnostic and Therapeutic Challenge-Case Report and Short Review," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 4(4), pages 70-73, July.
    • Handle: RePEc:adp:joajnn:v:4:y:2017:i:4:p:70-73
    DOI: 10.19080/OAJNN.2017.04.555647
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