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Neurotransmitter Storage and Recycling: Two Transporter Families Govern Complementary Synaptic Roles with Vast Medical Applications and Therapeutic Perspectives: A Commentary

Author

Listed:
  • Elías Leiva
  • J Pablo Huidobro-Toro

    (Department of Biology, University of Santiago, Chile)

Abstract

The storage of neurotransmitters in synaptic vesicles and its recycling, either intact or as a precursor molecule after its release, are two key concepts underlying the synaptic physiology that apply to both central and peripheral neurons. Although within the past 50 years we have vastly increased our understanding of the neurochemistry supporting transmitter synthesis, and the cytoarchitectural features of the nerve ending varicosities where these events take place, the cellular and molecular principles that govern transmitter storage and recycling are still elusive in many respects. We teach that transmitter storage and its reutilization are two separate events, causally related and depend on two distinct types of transporter proteins. One dependent of transporters recycles the transmitter back to the nerve terminal (reuptake) once it is released and in a second independent step, another transporter accumulates the neurotransmitter in the synaptic vesicles for its subsequent release.

Suggested Citation

  • Elías Leiva & J Pablo Huidobro-Toro, 2017. "Neurotransmitter Storage and Recycling: Two Transporter Families Govern Complementary Synaptic Roles with Vast Medical Applications and Therapeutic Perspectives: A Commentary," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 4(3), pages 35-38, June.
    • Handle: RePEc:adp:joajnn:v:4:y:2017:i:3:p:35-38
    DOI: 10.19080/OAJNN.2017.04.555636
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