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Drug Induced Parkinsonism: An Overview

Author

Listed:
  • Bahiya Sulthana
  • Sujith Ovallath

    (James Parkinson’s Research Centre, Kannur Medical College, India)

Abstract

Ever since 1950s from reserpine rat model to [18F] FP-CIT PET scan, our knowledge of drug induced Parkinsonism has been constantly evolving. Trend of suspected agents changed from typical antipsychotic to more commonly used drugs like Metoclopramide and more recently to newer prokinetics like levosulpiride. Even though DIP is mostly reversible, unmasking of subclinical PD and irreversible damage by the drug leads to persistent DIP. Demonstrated risk is higher with elderly and women. Symptoms can appear from 3 months (69%) to 12 months (20%) of the drug intake. Most of causative agents act by blocking the dopaminergic transmission in niagrostriatal pathway. The clinical syndrome is likely to present with subacute onset with symmetrical involvement. Presence of non-motor symptoms especially hyposmia and asymmetrical involvement is suggestive of degenerative Parkinsonism. DaT scan/SPECT are the investigation available to differentiate pure DIP from other forms. Management of this condition comprises of recognition of symptoms early identifying the offending agents and prompt discontinuation of the causal agent .

Suggested Citation

  • Bahiya Sulthana & Sujith Ovallath, 2017. "Drug Induced Parkinsonism: An Overview," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 3(4), pages 56-60, May.
    • Handle: RePEc:adp:joajnn:v:3:y:2017:i:4:p:56-60
    DOI: 10.19080/OAJNN.2017.03.555620
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