IDEAS home Printed from https://ideas.repec.org/a/adp/joajnn/v2y2017i5p92-100.html
   My bibliography  Save this article

Differential Expression of Kinases and Cell Cycle Proteins in EW

Author

Listed:
  • LFM Scinto

    (Cambridge Neuro diagnostics LTD, UK)

  • Changiz Geula

    (Northwestern University Medical School, USA)

Abstract

The Edinger-Westphal (EW) of the nucleus of cranial nerve III (NCNIII), in contrast to the somatic portion, is an early site of pathology and cell loss in Alzheimer’s disease (AD) and the aging brain. Cell loss in the EW accounts for the observed pupillary hypersensitivity in Alzheimer’s disease (AD) patients to challenge with dilute tropicamide that could potentially serve as a biomarker for AD. The remarkable specificity of pathophysiology and cell loss offers a possible heuristic model by which to study selective cell vulnerability. Neurochemical differences in the somatic and EW portions of the NCNIII may account for their differential vulnerability. The EW pathology consists of phosphorylated tau in oligomers, tangles and neurites. This suggests that neurochemicals shown to be critical to the metabolism and phosphorylation of tau may be differentially expressed at the protein level in these two cell groups. This study examined the cellular expression of Cdc2, Cdk5 kinases, the prolyl isomerase Pin 1 and mitotic phosphoepitopes visualized by MPM-2 using immunohistochemical methods. The results demonstrated that the expression of target neurochemicals differs in the EW as opposed to somatic cell groups and in AD patients versus controls. The variability in the expression of some of these proteins may account for the observed regionally specific pathophysiology and cell loss within the NCNIII and perhaps also other cell groups vulnerable in AD and ageing.

Suggested Citation

  • LFM Scinto & Changiz Geula, 2017. "Differential Expression of Kinases and Cell Cycle Proteins in EW," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 2(5), pages 92-100, March.
    • Handle: RePEc:adp:joajnn:v:2:y:2017:i:5:p:92-100
    DOI: 10.19080/OAJNN.2017.02.555599
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/oajnn/pdf/OAJNN.MS.ID.555599.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/oajnn/OAJNN.MS.ID.555599.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/OAJNN.2017.02.555599?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Michel Goedert, 1999. "Pinning down phosphorylated tau," Nature, Nature, vol. 399(6738), pages 739-740, June.
    2. Pei-Jung Lu & Gerburg Wulf & Xiao Zhen Zhou & Peter Davies & Kun Ping Lu, 1999. "The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein," Nature, Nature, vol. 399(6738), pages 784-788, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sukanta Jash & Sayani Banerjee & Shibin Cheng & Bin Wang & Chenxi Qiu & Asami Kondo & Jan Ernerudh & Xiao Zhen Zhou & Kun Ping Lu & Surendra Sharma, 2023. "Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:joajnn:v:2:y:2017:i:5:p:92-100. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.