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First Time in Human Study: Neuroseal Dural Sealant Prevents Cerebrospinal Fluid Leakage Following Elective Cranial Surgery

Author

Listed:
  • Pal Barzo

    (Department of Neurosurgery, University of Szeged, Albert Szent-Györgi Medical Center, Hungary)

  • Sandor Szabo

    (Department of Neurosurgery, Medical School University Debrecen, Hungary)

  • Peter Orbay

    (National Institute of Neurosurgery, Hungary)

  • Virginia Jamieson

    (Kuros Biosurgery AG, Switzerland)

Abstract

Cerebrospinal Fluid (CSF) leakage remains a significant cause of morbidity and mortality and can occur when no watertight Dural closure is achieved after neurosurgery. We carried out a retrospective clinical study to investigate the safety and effectiveness of a novel dural sealant, Neuroseal, to stop or prevent CSF leakage following elective cranial surgery. In a prospective, open, multi-center, single-arm study in 45 adult patients (n=38 completed) eligible patients received Neuroseal, a novel, colored synthetic dural sealant to augment dural closure following suturing of the dura.ssss

Suggested Citation

  • Pal Barzo & Sandor Szabo & Peter Orbay & Virginia Jamieson, 2020. "First Time in Human Study: Neuroseal Dural Sealant Prevents Cerebrospinal Fluid Leakage Following Elective Cranial Surgery," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 12(5), pages 118-125, January.
    • Handle: RePEc:adp:joajnn:v:12:y:2020:i:5:p:118-125
    DOI: 10.19080/OAJNN.2020.12.555850
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