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Glia Maturation Factor in the Pathogenesis of Alzheimer’s Disease

Author

Listed:
  • Swathi Beladakere Ramaswamy
  • Sachin M Bhagavan
  • Harleen Kaur
  • Gema E Giler
  • Smita Zaheer
  • Raghav Govindarajan

    (Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA)

  • Duraisamy Kempuraj
  • Ramasamy Thangavel
  • Mohammad Ejaz Ahmed
  • Govindhasamy Pushpavathi Selvakumar
  • Sudhanshu P Raikwar
  • Shankar S Iyer
  • Asgar Zaheer

    (Harry S Truman Memorial Veterans Hospital, US Department of Veterans Affairs, Columbia, MO, USA)

Abstract

Alzheimer’s Disease (AD) is a neurodegenerative and neuroinflammatory disease characterized by the presence of extracellular Amyloid Plaques (APs) and intracellular Neurofibrillary Tangles (NFTs) in the brain. There is no disease modifying therapeutic options currently available for this disease. Hippocampus, entorhinal cortex (Broadmann area 28), perirhinal cortex (Broadmann area 35) and insular cortices are areas within the brain that are first ones to be severely affected in AD. Neuroinflammation is an important factor that induces neurodegeneration in AD. Glia Maturation Factor (GMF), a proinflammatory factor plays a crucial role in AD through activation of microglia and astrocytes to release proinflammatory mediators in the brain

Suggested Citation

  • Swathi Beladakere Ramaswamy & Sachin M Bhagavan & Harleen Kaur & Gema E Giler & Smita Zaheer & Raghav Govindarajan & Duraisamy Kempuraj & Ramasamy Thangavel & Mohammad Ejaz Ahmed & Govindhasamy Pushpa, 2019. "Glia Maturation Factor in the Pathogenesis of Alzheimer’s Disease," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 12(3), pages 81-84, December.
    • Handle: RePEc:adp:joajnn:v:12:y:2019:i:3:p:81-84
    DOI: 10.19080/OAJNN.2019.12.555840
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