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Nutritional Regulation of Growth Hormone/ Insulin-like Growth Factor-1 Axis

Author

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  • Bo Ban

    (Department of Endocrine and Metabolic diseases, Hospital of Jining Medical University, China)

  • Qianqian Zhao

    (Jining Medical University, China)

Abstract

The growth hormone (GH)/insulin-like growth factor-1 (IGF-1), a central growth-regulatory system in human, can be affected by multiple factors, of which nutrition is an important regulatory factor. Low GH/IGF-1 status is usually regarded as a functional condition of nutritional disorder, and it could be largely reversible after a nutritional supplement. The GH/IGF-1 axis consists of a series of finely regulated molecular mechanisms that are susceptible to protein calorie deficiency. In addition, malnutrition could induce the nutritionally responsive proteins that block hepatic GH signal transduction by inhibiting the JAK/STAT pathway, thereby limiting the generation of IGF-1. Taken together, nutrition is an important regulator of for human growth and development. However, to date, the association between nutrition and GH/IGF-1 axis remains incompletely understood. The present paper aims at reviewing existing literatures on the probable effects of nutrition on the GH/IGF-1 axis.

Suggested Citation

  • Bo Ban & Qianqian Zhao, 2018. "Nutritional Regulation of Growth Hormone/ Insulin-like Growth Factor-1 Axis," Nutrition & Food Science International Journal, Juniper Publishers Inc., vol. 7(5), pages 154-156, November.
    • Handle: RePEc:adp:jnfsij:v:7:y:2018:i:5:p:154-156
    DOI: 10.19081/NFSIJ.2018.07.555725
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