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Supramolecular Synthons as Related to Cooperativity in Biocomplexes: towards Design and Development of Oligopeptide-Based Modern Drugs and Cosmeceuticals

Author

Listed:
  • Joanna Bojarska
  • Wojciech M. WOLF

    (Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromski St. 116, 90-924 todz, Poland)

  • Krzysztof Kaczmarek
  • Janusz Zabrocki

    (Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromski St. 116, 90-924 todz)

Abstract

Short oligopeptides of natural and synthetic origin are becoming increasingly important not only in research and modern drugs development but also as cosmeceuticals. On the other hand, complexes of proteins with peptide ligands have attracted wide attention in biomedicine. In particular, in silico and in vivo drug development is concerned. Therefore, detailed knowledge on supramolecular and energetic aspects of protein-peptide weak non-covalent interactions and their systematic evaluation is essential. In this mini review, we shed light into increasing potential of supramolecular synthon approach when cooperative effects in stabilization of biomolecules are to be concerned. We put forward the views on interpretation of protein–peptide ligand binding modes and the future development of innovative APIs.

Suggested Citation

  • Joanna Bojarska & Wojciech M. WOLF & Krzysztof Kaczmarek & Janusz Zabrocki, 2019. "Supramolecular Synthons as Related to Cooperativity in Biocomplexes: towards Design and Development of Oligopeptide-Based Modern Drugs and Cosmeceuticals," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 5(2), pages 23-25, June.
    • Handle: RePEc:adp:jnapdd:v:5:y:2019:i:2:p:23-25
    DOI: 10.19080/NAPDD.2019.05.555656
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