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Annexin 2 Protein Expression is Associated with Breast Cancer Subtypes in African American Women

Author

Listed:
  • Desta A Beyene

    (Department of Biochemistry and Molecular Biology, Howard University, USA
    Department of Research, Veteran Affairs Medical Center, USA
    Howard University Cancer Center, USA)

  • Norma F Kanarek

    (Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, USA)

  • Tammey J Naab

    (Department of Pathology, Howard University, USA)

  • Santa L Ricks

    (Department of Biological Sciences, Hampton University, USA)

  • Tamaro S Hudson

    (Department of Research, Veteran Affairs Medical Center, USA
    Department of Pharmacology, Howard University, USA
    Howard University Cancer Center, USA)

Abstract

Breast cancer is the most common cancer diagnosis and the second leading cause of death among American women [1]. African American breast cancer patients of all ages are more likely to have advanced disease at diagnosis, an increased risk of recurrence and a poorer prognosis compared with their Caucasian counterparts [2,3]. Tumor stage, tumor grade and lymph node metastasis are commonly used as prognostic factors for breast cancer [4]. However, these are not sufficient for accurately predicting [4]. Therefore, biomarkers are needed to more accurately predict survival outcome. Considering the role of ANX2 in tumorigenesis and metastasis its use as prognostic marker for breast cancer needs to be investigated.

Suggested Citation

  • Desta A Beyene & Norma F Kanarek & Tammey J Naab & Santa L Ricks & Tamaro S Hudson, 2019. "Annexin 2 Protein Expression is Associated with Breast Cancer Subtypes in African American Women," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 4(5), pages 125-133, January.
    • Handle: RePEc:adp:jnapdd:v:4:y:2019:i:5:p:125-133
    DOI: 10.19080/NAPDD.2019.04.555650
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