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Saliva versus Blood Therapeutic Drug Monitoring of Tacrolimus in Jordanian Kidney Transplant Patients

Author

Listed:
  • Salim Hamadi
  • Fathia Banna
  • Nasir Idkaidek

    (University of Petra, College of Pharmacy, Jordan)

  • Izzat Al-Awwa

    (Jordan university hospital, Amman, Jordan)

  • Ahmad Al-Ghazawi

    (Triumpahrma LLC, Amman, Jordan)

Abstract

Tacrolimus is a macrolide antibiotic with immunosuppressive properties, it is indicated as primary immunosuppressive therapy following liver, heart and kidney transplantation, because of its better survival results and less acute cellular rejection than cyclosporine. The main objectives of this study are to investigate the robustness of using a non- invasive saliva sampling method instead of a blood sampling method as a surrogate for therapeutic drug monitoring (TDM) of tacrolimus among Jordanian patients, develop validated, sensitive and specific method (LC-MS/MS) for determination of tacrolimus in blood and saliva, determine the correlation between blood tacrolimus concentration versus saliva tacrolimus concentration and determine the variability in pharmacokinetic parameters of tacrolimus among patients to individualize dosage regimen. Forty two patients participated in this study. Two samples were collected from each patient two hours before morning dose, one sample is blood, and another is resting saliva sample.

Suggested Citation

  • Salim Hamadi & Fathia Banna & Nasir Idkaidek & Izzat Al-Awwa & Ahmad Al-Ghazawi, 2018. "Saliva versus Blood Therapeutic Drug Monitoring of Tacrolimus in Jordanian Kidney Transplant Patients," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 4(2), pages 33-37, September.
    • Handle: RePEc:adp:jnapdd:v:4:y:2018:i:2:p:33-37
    DOI: 10.19080/NAPDD.2018.04.555632
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