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Design and Synthesis and In-Vitro Assay Of Substituted 2-Aminobenzamide Derivatives

Author

Listed:
  • Vivekanand A Chatpalliwar

    (SNJB’s College of Pharmacy, Savitribai Phule Pune University, India)

  • Ravindra R Patil
  • Mansi D
  • Saurabh CK

    (RC Patel Institute of Pharmaceutical Education and Research, Shirpur, India)

Abstract

Glucokinase has been unearthed in the past decade to be a strategic drug target for T2DM as it is implemented dually in increasing pancreatic insulin secretion and enhancing hepatic glucose metabolism. The research carried was to design, conduct in silico interaction studies, synthesize few of the accepted benzamide derivatives as GK activators (GKA) on the basis of the SAR studies and there in silico interactions with the enzyme. All molecular modeling studies were performed using the Molecular Design Suite (VLife MDS software package, version 3.5), and LigPrep (v2.2) module in the Schrodinger software molecular simulations. RCSB/PDB site was explored to study the simulated protein structures available and 1V4S-representing the simulated protein. Ligands from the studies were selected for synthesis, characterized, and subjected to in vitro glucokinase assay. Detail synthetic procedures, purifying methods, characterizations of the synthesized compounds, methodologies of in vitro assays, and the inferences drawn from the ensued observations are discussed at large. The results of the in silico studies and in vitro assay are presented.

Suggested Citation

  • Vivekanand A Chatpalliwar & Ravindra R Patil & Mansi D & Saurabh CK, 2017. "Design and Synthesis and In-Vitro Assay Of Substituted 2-Aminobenzamide Derivatives," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(2), pages 36-45, November.
    • Handle: RePEc:adp:jnapdd:v:3:y:2017:i:2:p:36-45
    DOI: 10.19080/NAPDD.2017.03.555609
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