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Differential Distribution of GABA and Gat1 in Mouse Epididymis

Author

Listed:
  • Zhang Jinfu

    (Department of Urology, Shanghai Tongren Hospital, China)

  • Zhang Wenping
  • Qi Lixin

    (Department of Dermatology, Tongji Hospital of Tongji University School of Medicine, China)

  • Le Wei

    (Department of Urology, Tongji Hospital of Tongji University School of Medicine, China)

  • Hu Jiahua
  • Lihee Guo

    (Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, China)

  • Huai L Feng

    (Department of Obstetrics and Gynecology, Medical College of Cornell University, USA)

Abstract

The present study showed a detailed description of distribution of GABA and its transporter protein GAT1 in mouse epididymis and gave insight into the physiological function of GABA in mouse epididymis. The location of GABA and GAT1 in epididymis was detected by immunohistochemistry assay. Histological distribution of GABA and GAT1 was observed under microscope in different resolution. The staining of different parts of epididymis was quantified. The semi-quantification data showed that the GABA staining of epididymis caput is dramatically stronger than corpus and cauda, and GABA distribution in mouse epididymis paralleled with GAT1. These data suggest that GABA system performs its function mostly in the caput of mouse epididymis and epididymis caput might be crucial for sperm maturation.

Suggested Citation

  • Zhang Jinfu & Zhang Wenping & Qi Lixin & Le Wei & Hu Jiahua & Lihee Guo & Huai L Feng, 2017. "Differential Distribution of GABA and Gat1 in Mouse Epididymis," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(2), pages 32-35, November.
    • Handle: RePEc:adp:jnapdd:v:3:y:2017:i:2:p:32-35
    DOI: 10.19080/NAPDD.2017.03.555608
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