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Functional Selective D2 Ligands for the Treatment of Schizophrenia

Author

Listed:
  • Xin Chen
  • Giuseppe Gumina

    (Department of Pharmaceutical and Administrative Sciences, USA)

Abstract

Functionally selective ligands (also known as biased ligands) of dopamine D2 receptors have been considered as not only valuable tools for dissecting the roles of D2-mediated G protein-dependent and independent signaling pathways, but also better antipsychotic drug candidates for neurological and psychiatric disorders including schizophrenia. Consequently, functionally selective D2R ligands have also been increasingly pursued by the biomedical community as promising antipsychotic therapeutics with improved efficacy and reduced side effects compared with unbiased ligands. This review will discuss the recent development in the discovery of functional selective D2R ligands Figure 1.

Suggested Citation

  • Xin Chen & Giuseppe Gumina, 2017. "Functional Selective D2 Ligands for the Treatment of Schizophrenia," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(1), pages 3-8, October.
    • Handle: RePEc:adp:jnapdd:v:3:y:2017:i:1:p:3-8
    DOI: 10.19080/NAPDD.2017.03.555602
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