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PPARα as Potential Therapeutic Target for Neurodegenerative Diseases

Author

Listed:
  • Letizia Giampietro
  • Rosa Amoroso

    (Department of Pharmacy, university G.d’ Annunzio, Italy)

Abstract

Peroxisome proliferator activated receptor α (PPARα) is ligand-activated transcriptional factor receptor belonging to nuclear receptors family. It plays a key role in lipid metabolism and glucose homeostasis and it is important in the prevention and treatment of metabolic diseases. PPARα has also a protective effects against brain cell death attributed to its anti-inflammatory and antioxidant properties. In the present work, we discuss the PPAR involvement in neurodegenerative pathologies and its potential as therapeutic target for these diseases.

Suggested Citation

  • Letizia Giampietro & Rosa Amoroso, 2017. "PPARα as Potential Therapeutic Target for Neurodegenerative Diseases," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(5), pages 98-101, October.
    • Handle: RePEc:adp:jnapdd:v:2:y:2017:i:5:p:98-101
    DOI: 10.19080/NAPDD.2017.02.555599
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