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Modelling of Drug Release from a Polymer Matrix System

Author

Listed:
  • Luke EK Achenie
  • Naresh Pavurala

    (Department of Chemical Engineering, Virginia Tech, USA)

Abstract

A drug release model is proposed to predict the behaviour of an oral drug tablet as it traverses the gastrointestinal (GI) tract. The model predicts the rate of change of tablet dimensions. The effect of polymer degradation rate on the tablet dissolution time and drug release kinetics is analyzed. The total tablet dissolution time decreases with increase in the polymer degradation rate constant (dk). A simpler second model (power law) is also offered to describe the relationship between tablet dissolution time and dk . The model predicts initial burst release of the drug followed by nearly constant release.

Suggested Citation

  • Luke EK Achenie & Naresh Pavurala, 2017. "Modelling of Drug Release from a Polymer Matrix System," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(3), pages 54-63, July.
    • Handle: RePEc:adp:jnapdd:v:2:y:2017:i:3:p:54-63
    DOI: 10.19080/NAPDD.2017.02.555589
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