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New Promises of Chemical Proteomics for Drug Development

Author

Listed:
  • Massimiliano Gaetani
  • Roman A Zubarev

    (Department of Medical Biochemistry and Biophysics, Karolinska Institute, Sweden)

Abstract

The road to development of a new drug often begins with the idea of its target protein, which could result from evidence emerging from different research sources, including academia, clinics and industry. However, taking a single compound to the drug market involves a very high cost, often over a billion of US dollars, and requires on average a time commitment between ten and fifteen years. The entire process is very complicated and, even in the lucky cases when the final development steps are reached, it sometimes collapses because of a failure related to the drug target, which is its starting point. Indeed, one of the major reasons of drug failures in clinical trials is the lack of efficacy due to low specificity of the drug towards the desired target. Sometimes, when the promising candidate compound is found in a large-scale phenotypic screening, the target is not even known a priori.

Suggested Citation

  • Massimiliano Gaetani & Roman A Zubarev, 2017. "New Promises of Chemical Proteomics for Drug Development," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(1), pages 12-14, June.
    • Handle: RePEc:adp:jnapdd:v:2:y:2017:i:1:p:12-14
    DOI: 10.19080/NAPDD.2017.02.555579
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