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Islet Cell Transplantation for Treating Type 1 Diabetes: The Bright Future of Drug Designing and Development

Author

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  • Mina T Kelleni

    (Department of pharmacology, Minya University, Egypt)

Abstract

The revolutionary process of islet transplantation for treating type 1 diabetes has been limited by the high level of graft failure. The process of islet isolation alone has been shown to negatively impact islet survival and function in vivo. In addition, insults mediated by the instant blood-mediated inflammatory reaction, hypoxia, ischemia and immune response significantly impact the islet allograft post transplantation [1,2]. Moreover, the immune response to alloantigens and recurrence of autoimmunity contribute to pancreatic islet transplant dysfunction [3].

Suggested Citation

  • Mina T Kelleni, 2017. "Islet Cell Transplantation for Treating Type 1 Diabetes: The Bright Future of Drug Designing and Development," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 1(3), pages 50-51, June.
    • Handle: RePEc:adp:jnapdd:v:1:y:2017:i:3:p:50-51
    DOI: 10.19080/NAPDD.2017.01.555564
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