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Procalcitonin- A Biomarker Must Explicate Prudently

Author

Listed:
  • Menka Kapil
  • Rateesh Sareen
  • Alok Verma
  • Gupta Gn

    (Department of Pathology, Medical Research Institute, India)

Abstract

Procalcitonin is 116 amino acid peptide that belongs to the calcitonin superfamily of peptides it is an acute-phase reactant protein made by the C cells of the thyroid gland [1]. Outside from the thyroid gland, it is also produced by lungs, kidneys, liver [2] and other tissues in increasing amounts in response to bacterial endotoxin in the bloodstream. This makes PCT a more specific biomarker for infection than acute phase reactants like erythrocyte sedimentation rate or C-reactive protein. Procalcitonin is a useful marker for the diagnosis of systemic inflammatory response that is one of the primary responses to microbial invasion [3] which leads to systemic illness which is known as sepsis. Several studies on plasma procalcitonin have demonstrated its role in the diagnosis of sepsis, prognosis of acute severe pancreatitis and even as a prognostic marker following major surgery [4,5].

Suggested Citation

  • Menka Kapil & Rateesh Sareen & Alok Verma & Gupta Gn, 2019. "Procalcitonin- A Biomarker Must Explicate Prudently," JOJ Internal Medicine, Juniper Publishers Inc., vol. 1(2), pages 60-61, November.
    • Handle: RePEc:adp:jjojim:v:1:y:2019:i:2:p:60-61
    DOI: 10.19080/JOJIM.2019.01.555562
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