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The Debate on Podophyllin in Pregnancy

Author

Listed:
  • Khalifa E Sharquie
  • Luma H Al-Taha

    (Dermatology Centre, Medical City, Iraq)

Abstract

After the discovery of podophyllum resin in 1835, it was put to numerous uses. However, it was only in 1942 that Kaplan put it to the use for the treatment of venereal warts. A formal regulatory review and safety evaluation of podophyllin has never been performed till 2001. Bargman in 1988 has reviewed the whole subject of systemic toxicity to podophyllin including its reported teratogenicity. He noted that in almost all cases there were factors (such as alcohol or drug abuse, recent surgical procedures, general anesthesia) which may have potentiated the toxicity of podophyllin. Since nearly all reported cases have been blacks, he also considered the possibility of an unsuspected racial susceptibility. He concluded that the dangers of podophyllin toxicity have been over-played, and that it is an extremely safe drug when used properly, so we were noticed from our clinical experience.

Suggested Citation

  • Khalifa E Sharquie & Luma H Al-Taha, 2020. "The Debate on Podophyllin in Pregnancy," JOJ Dermatology & Cosmetics, Juniper Publishers Inc., vol. 3(1), pages 4-5, June.
    • Handle: RePEc:adp:jjojdc:v:3:y:2020:i:1:p:4-5
    DOI: 10.19080/JOJDC.2020.03.555602
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