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Formulation and Optimization of Nanoparticale by 32 Factorial Design for Colon Targeting

Author

Listed:
  • Ganesh S Bangale

    (Government College of Pharmacy, Amravati (M.S.), India)

  • GV Shinde

    (Parul Institute of Pharmacy, Baroda, India)

  • Rajesh KS

    (I.S.F. College of Pharmacy, Moga, India)

Abstract

The aim of the present study was to develop stable nanoparticulate formulation for sustained release of Prednisolone. Chitosan nanoparticles were prepared by ionic gelation method using tripolyphosphate as cross-linking agent. Different nanoparticulate formulations were prepared by using 32 factorial design in which varying the concentration of chitosan (0.1% to 0.3%), concentration of tripolyphosphate (0.02% to 0.03%) as two factors. The effect of these factors on the particle size, % entrapment efficiency and in vitro drug release was evaluated to develop an optimized formulation.

Suggested Citation

  • Ganesh S Bangale & GV Shinde & Rajesh KS, 2019. "Formulation and Optimization of Nanoparticale by 32 Factorial Design for Colon Targeting," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 7(1), pages 8-22, January.
    • Handle: RePEc:adp:jgjpps:v:7:y:2019:i:1:p:8-22
    DOI: 10.19080/GJPPS.2019.07.555702
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