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Impact of Cialis on Haemoglobin Concentration and Lipid Profile of Wistar Male Rats

Author

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  • Nzor Joyce Nornubari
  • Okari Karibo Amakiri

    (Department of Biochemistry, University of Port Harcourt, Nigeria)

Abstract

Erectile dysfunction (ED) is the consistent or recurrent inability of a man to attain and/or maintain a penile erection enough for sexual activity, currently phosphodiesterase (PDE) inhibitors are used in the treatment of erectile dysfunction. This research work is set out to determine the lipid profile and haemoglobin concentration of wistar male rats administered with cialis, forty-five male albino wistar rats with an average weight of 100 g were used for the study. Cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides concentration increased non-significantly at the 7th, 14th and 21st day following treatment, haemoglobin concentration also increased but its increase was significant as compared to the control animals. The elevated lipid profile with corresponding increase in hematocrit is as a result of reverse cholesterol transport mechanism. However due to the observed effect of the drug on lipid profile, utilization of the drug should be monitored as elevated lipid profile could pose as a risk factor for the development of other diseases.

Suggested Citation

  • Nzor Joyce Nornubari & Okari Karibo Amakiri, 2019. "Impact of Cialis on Haemoglobin Concentration and Lipid Profile of Wistar Male Rats," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 6(5), pages 121-123, January.
    • Handle: RePEc:adp:jgjpps:v:6:y:2019:i:5:p:121-123
    DOI: 10.19080/GJPPS.2019.06.555699
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