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Development and Validation of A RP- HPLC Method for the Simultaneous Estimation of Valsartan and Sacubitril in Rat Plasma

Author

Listed:
  • N Anjaneyulu
  • R Naga Kishore
  • M Ravi Kumar
  • G Sneha

    (Department of Pharmaceutical Analysis, Geethanjali College of Pharmacy, India)

Abstract

A basic precise selective, sensitive isocratic technique was developed and valid for the quantitative synchronic estimation of Sacubitril and Valsartan drug in rat plasma was by RP- HPLC system. The chromatographic activity separation was administrated out on Intersil C18 (250 x 4.6mm, 5μm) column with a mix of acetonitrile: di-potassium hydrogen phosphate, pH 3.0 adjusted with Phosphate buffer (30:70%v/v) as mobile part. The analytes were eluted with a rate of flow of 0.8ml/min and at a wavelength of 371nm of UV detection. The strategy was valid for precision, accuracy, linearity, Limit of detection, Limit of Quantification, Ruggedness following the ICH guidelines.

Suggested Citation

  • N Anjaneyulu & R Naga Kishore & M Ravi Kumar & G Sneha, 2018. "Development and Validation of A RP- HPLC Method for the Simultaneous Estimation of Valsartan and Sacubitril in Rat Plasma," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 6(5), pages 105-110, December.
    • Handle: RePEc:adp:jgjpps:v:6:y:2018:i:5:p:105-110
    DOI: 10.19080/GJPPS.2018.06.555697
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