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A Clinical Review on Huntington Disease

Author

Listed:
  • Pooja Malkani
  • Prince Raj
  • Amit Singh

    (M. Pharm Research Scholar, Monad University, Uttar Pradesh)

Abstract

Huntington disease (HD) is a progressive, fatal, neurodegenerative disorder caused by an expanded (Cytosine, Adenine, Guanine) CAG repeat in the huntingtin gene, which encodes an abnormally long polyglutamine repeat in huntingtin protein. HD is characterised by unwanted choreatic movements, behavioural and psychiatric disturbances and dementia. HD is an autosomal dominant inherited disease caused by an elongated CAG repeat (36 repeats or more) on the short arm of chromosome 4p16.3 in huntingtin gene. The longer the CAG repeat, and then the onset of disease is earlier.

Suggested Citation

  • Pooja Malkani & Prince Raj & Amit Singh, 2018. "A Clinical Review on Huntington Disease," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 6(4), pages 88-92, October.
    • Handle: RePEc:adp:jgjpps:v:6:y:2018:i:4:p:88-92
    DOI: 10.19080/GJPPS.2018.06.555693
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