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Peg-5 Oleate Based Self Microemulsifying Drug Delivery System: As a Versatile Approach in Oral Bioavailability Enhancement of Anti-Diabetic Agent: Formulation Design, vitro/In vivo Evaluation & Stability Studies

Author

Listed:
  • Vikas Pandey

    (Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, India)

  • Seema Kohli

    (Departmen of Pharmaceutical Sciences, Kalaniketan Polytechnic College, India)

Abstract

The rationale of this research work was to develop and characterize self-micro emulsifying drug delivery system (SMEDDS) of repaglinide (RPG). The solubility of RPG was analyzed in various excipients. Pseudo ternary phase diagram was used to evaluate the micro-emulsification existence area. SMEDDS formulation (ME1, ME2, ME3, ME4&ME5) were examined for micro-emulsifying properties, and the consequential formulations loaded with RPG were investigated for clarity, phase separation, globule size and shape, zeta potential, thermodynamic and thermal stability. Out of five formulations developed three (ME1 , ME2&ME3) were found to be suitable from the point of view of above mentioned parametrical studies and were consecutively subjected to stability studies as per International conference on Harmonization (ICH) guidelines. Accelerated and long term conditions of a period of 3 months indicated no such noteworthy changes. TEM micrographs of microemulsion formulations further assured the spherical shape of globules. Developed SMEDDS formulation showed superior performance in in-vitro drug release and in-vivo studies in contrast to marketed RPG formulation (tablets) and pure RPG drug.

Suggested Citation

  • Vikas Pandey & Seema Kohli, 2018. "Peg-5 Oleate Based Self Microemulsifying Drug Delivery System: As a Versatile Approach in Oral Bioavailability Enhancement of Anti-Diabetic Agent: Formulation Design, vitro/In vivo Evaluation & Stabil," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 5(5), pages 103-113, April.
    • Handle: RePEc:adp:jgjpps:v:5:y:2018:i:5:p:103-113
    DOI: 10.19080/GJPPS.2018.05.555671
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