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99mTc Labeled L-Tryptophan Conjugated Macrocyclic Chelating Agent: Synthesis, Characterization and In Vitro & In Vivo Biological Studies

Author

Listed:
  • Ranjeet Kumar
  • Bachcha Singh

    (Department of Chemistry, Banaras Hindu University, India)

  • Ankur Kaul
  • Anil K Mishra

    (Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, India)

Abstract

Radiolabeled amino acids and their derivatives are an important class of imaging agents for PET and SPECT that target the increased levels of amino acid transport by many tumour cells. The novel amino acid (L-tryptophan methyl ester) based legend; 16Trp4A was successfully synthesized and well characterized through spectroscopic techniques and mass spectrometry which may be used as imaging agents. The pharmacokinetics of these compounds was analyzed by 99mTc labeled tracer methods. The labelling yield was found to be greater than 95%, as determined chromatographically by different solvent. Bio distribution studies in mice revealed significant uptake in blood, lung, liver, kidney, spleen and intestine initially, which decreases as time passes up to 24h. The maximum uptake of 99mTc -16Trp4A was found in liver 9.61+0.33, 5.95+0.29 and 3.66+0.19 %ID/g at 1,4 and 24h post injection, respectively, concluded that excretory pathway is hepatobiliary. Accumulation of activity in non-targeted organs and tissues (heart, brain, lungs, stomach, and intestine) was found

Suggested Citation

  • Ranjeet Kumar & Bachcha Singh & Ankur Kaul & Anil K Mishra, 2018. "99mTc Labeled L-Tryptophan Conjugated Macrocyclic Chelating Agent: Synthesis, Characterization and In Vitro & In Vivo Biological Studies," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 5(3), pages 56-59, March.
    • Handle: RePEc:adp:jgjpps:v:5:y:2018:i:3:p:56-59
    DOI: 10.19080/GJPPS.2018.05.555661
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