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Protective Effect of Purple Grape Juice on Homocysteine - Induced Oxidative Stress

Author

Listed:
  • Elif KaÄŸa
  • Ayhan Vurmaz
  • Ahmet Kahraman

    (Department of Biochemistry, Afyon Kocatepe University, Turkey)

Abstract

The objective of this study was to evaluate the protective role of purple grape juice against oxidative damage induced by hyperhomocysteinemia in rats. For this purpose, rats were divided into 4 groups: Rats in the control group (n=8) received tap water with gavage and intraperitoneal (i.p.) saline solution (1ml/kg/day) for 30 days. Rats in the purple grape juice group (PGJ) (n=8) received purple grape juice (10ml/kg/day) with gavage and saline solution (1ml/kg/day). Rats in the homocysteine group (HCY) (n=8) received i.p. homocysteine (1ml/kg/day) and tap water (10ml/kg/day) with gavage. Rats in the purple grape juice+homocysteine group (PGJ+HCY) (n=8) received i.p. homocysteine (1ml/kg/day) and grape juice (10ml/kg/day) with gavage. During the study, plasma malondialdehyde (MDA), plasma carbonyl were assessed as indicators of oxidative stress; erythrocyte reduced glutathione (GSH), plasma sulfhydryl (SH) levels and erythrocyte catalase (CAT) and erythrocyte superoxide dismutase (SOD) activities were assessed as indicators of antioxidant capacity.

Suggested Citation

  • Elif KaÄŸa & Ayhan Vurmaz & Ahmet Kahraman, 2018. "Protective Effect of Purple Grape Juice on Homocysteine - Induced Oxidative Stress," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 5(2), pages 65-72, April.
    • Handle: RePEc:adp:jgjpps:v:5:y:2018:i:2:p:65-72
    DOI: 10.19080/GJPPS.2018.05.555663
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