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Comparative In-Vitro Equivalence Evaluation of Fexofenadine Hydrochloride 120mg Generic Tablets Marketed in Bangladesh

Author

Listed:
  • Sabreena Chowdhury Raka
  • BSM Bodiuzzaman

    (Department of Pharmacy, Daffodil International University, Bangladesh)

  • Arifur Rahman

    (Department of Pharmacy, BRAC University, Bangladesh)

Abstract

Fexofenadine hydrochloride, a piperidine derivative, is indicated to relieve signs and symptoms related with seasonal allergic rhinitis, such as rhinorrhoea, sneezing nose, throat and itchy eyes. The aim of my study is to establish the pharmaceutical equivalence of different brands of fexofenadine hydrochloride 120mg film coated tablets available in Bangladesh. The quality control parameters which are studied are weight variation test, thickness, friability, hardness, disintegration, dissolution and assay specified by British and United State Pharmacopoeia. The assay value was determined by HPLC. Out of the tablets from six evaluated pharmaceutical companies, the potency of fexofenadine hydrochloride tablets from four companies was found to be satisfactory and two was poor of the range.

Suggested Citation

  • Sabreena Chowdhury Raka & BSM Bodiuzzaman & Arifur Rahman, 2017. "Comparative In-Vitro Equivalence Evaluation of Fexofenadine Hydrochloride 120mg Generic Tablets Marketed in Bangladesh," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 3(1), pages 6-11, June.
    • Handle: RePEc:adp:jgjpps:v:3:y:2017:i:1:p:6-11
    DOI: 10.19080/GJPPS.2017.03.555602
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