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Simultaneous UV Spectrophotometric Estimation of Acebutalol Hydrochloride and Hydrochlorothiazide in Bulk and Combined Tablet Dosage Form

Author

Listed:
  • Pawar Seemarani
  • Jadhav S
  • Tamboli A
  • Shaikh A
  • Mali S

    (Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, India)

Abstract

There is not a single analytical methods appeared in the literature for combined estimation of Acebutalol Hydrochloride and Hydrochlorothiazide in tablets dosage form. Attempts were made to develop a simple, precise and accurate Simultaneous UV spectroscopic method of Acebutalol Hydrochloride and Hydrochlorothiazide in bulk and Sectrazide tablet dosage form by using simultaneous equation method. UV spectrophotometric method was developed and validated as per ICH guidelines using methanol as mobile phase. Acebutalol Hydrochloride and Hydrochlorothiazide individually follows the Beer-Lamberts law over concentration range 3-18μg/ml and 1-6μg/ml, regression of coefficient was found to be r2=0.9999 and r2=0.9999 respectively. The percentage recovery was found in the range of 98% to 102% at three different levels. The proposed method was successfully applied for the determination of Acebutalol Hydrochloride and Hydrochlorothiazide in tablets dosage form as per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.

Suggested Citation

  • Pawar Seemarani & Jadhav S & Tamboli A & Shaikh A & Mali S, 2017. "Simultaneous UV Spectrophotometric Estimation of Acebutalol Hydrochloride and Hydrochlorothiazide in Bulk and Combined Tablet Dosage Form," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 3(1), pages 15-18, June.
    • Handle: RePEc:adp:jgjpps:v:3:y:2017:i:1:p:15-18
    DOI: 10.19080/GJPPS.2017.03.555604
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