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Is There a Role Of Resveratrol in Doxorubicin- Induced Hepatotoxicity?

Author

Listed:
  • Dorsaf Ben Gaied
  • Arnaud P

    (Unité de Technologies Chimiques et Biologiques pour la Santé, Faculty of pharmacy of Paris, France)

Abstract

Doxorubicin (DOX) has been used in the treatment of variety of cancers but its administration is limited by a dose-dependent toxicity. Its cytotoxic effects on malignant cells, have shown an increase in the risk of cardiotoxicity, hepatoxicity, renal failure. Antioxydants have been explored for both their cancer preventive properties and chemodulatory of DOX toxicity. Resveratrol (RSV) is a polyphenolic constituent of several dietary mainly of grapes and wine origin recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in-vitro and in-vivo. RSV is also known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, RSV have a great medicinal value, its applications as a therapeutics are limited.

Suggested Citation

  • Dorsaf Ben Gaied & Arnaud P, 2017. "Is There a Role Of Resveratrol in Doxorubicin- Induced Hepatotoxicity?," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 3(1), pages 12-14, June.
    • Handle: RePEc:adp:jgjpps:v:3:y:2017:i:1:p:12-14
    DOI: 10.19080/GJPPS.2017.03.555603
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