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Extractive Spectrophotometric Methods for the Determination of Dothiepin in Pure and Pharmaceutical Formulations

Author

Listed:
  • Umamaheswar K
  • Naganjaneyulu T
  • Rambabu C

    (Department of Chemistry, Acharya Nagarjuna University, India)

Abstract

Two sensitive and accurate extractive spectrophometric methods have been developed for the estimation of dothiepin in pure and pharmaceutical dosage forms. The developed methods are based on the formation of colored solvent extractible ion-association complexes of the drug with bromocresol blue [BCB] and eriochrome black-T [EBT]. The extracted complexes showed absorbance maxima at 418 and 508 nm respectively. Beer’s law is obeyed in the concentration ranges between 16 - 56 and 5-17.5μg/mL for the two methods respectively. The effective concentration of dye, pH and optimum conditions are established for these methods. The methods are applied for the determination of the drug in commercial tablets and results of analysis are validated statistically through recovery studies.

Suggested Citation

  • Umamaheswar K & Naganjaneyulu T & Rambabu C, 2017. "Extractive Spectrophotometric Methods for the Determination of Dothiepin in Pure and Pharmaceutical Formulations," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 2(2), pages 25-29, May.
    • Handle: RePEc:adp:jgjpps:v:2:y:2017:i:2:p:25-29
    DOI: 10.19080/GJPPS.2017.02.555582
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