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Genotoxicity: Mechanisms, Testing Guidelines and Methods

Author

Listed:
  • Mohamed SAKS
  • Sabita Upreti
  • Rajendra SV
  • Raman Dang

    (Krupanidhi College of Pharmacy, India)

Abstract

Genotoxicity is one of the major causes for cancer. Genotoxins are agents that can cause the damage of DNA or chromosomal structure thereby causing mutations. It can be chemical or radiation. This damage in the somatic cells will lead to various diseases ranging to cancer whereas the damage to the germ cell will lead to heritable diseases. Better identification and understanding of genotoxins would enable us to prevent the potential damage that can be caused by these genotoxic agents. In this article we discuss about the basic of genotoxicity and the importance of genotoxic studies.

Suggested Citation

  • Mohamed SAKS & Sabita Upreti & Rajendra SV & Raman Dang, 2017. "Genotoxicity: Mechanisms, Testing Guidelines and Methods," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 1(5), pages 133-138, April.
    • Handle: RePEc:adp:jgjpps:v:1:y:2017:i:5:p:133-138
    DOI: 10.19080/GJPPS.2017.01.555575
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