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Formulation and Evaluation of Solid Dispersion of Glimepiride in to Sustained Release

Author

Listed:
  • Anusha Pagadala
  • Madhuri Asiniparthi
  • Vaidehi Donti

    (Pharmaceutics Department, Gyana Jyothi College of Pharmacy, India)

Abstract

A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers.

Suggested Citation

  • Anusha Pagadala & Madhuri Asiniparthi & Vaidehi Donti, 2016. "Formulation and Evaluation of Solid Dispersion of Glimepiride in to Sustained Release," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 1(2), pages 18-22, June.
    • Handle: RePEc:adp:jgjpps:v:1:y:2016:i:2:p:18-22
    DOI: 10.19080/GJPPS.2016.01.555553
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