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Metformin Reduces the Extent of Varicocele-Induced Damage in Testicular Tissue

Author

Listed:
  • Erkan Erdem

    (Department of Urology, Ota-Jinemed Hospital, Turkey)

  • Nazli Ece Güngör-Ordueri

    (Department of Histology and Embriyology, Biruni University, Turkey)

  • Akin Usta

    (Department of Obstetrics and Gynecology, Balikesir Univesity, Turkey)

  • Cenk Kığ

    (Department of Medical Biology and Genetics, Yeni Yuzyil University, Turkey)

  • Meric Karacan

    (Department of Obstetrics and Gynecology, Yeni Yuzyil University, Turkey)

Abstract

Varicocele is a medical condition where retrograde flow of blood leads to increased hydrostatic pressure in testicular veins and the prevalence of varicocele is predicted to vary between 30 to 40% in infertile men. Metformin, major therapeutic agent in the treatment of type 2 diabetes mellitus, was shown to reduce oxidative stress and apoptosis in renal tubular epithelial cells and testis of animal models. However potential protective effects of metformin against varicocele-induced testicular damage has not been studied. We investigated the impact of metformin on spermatogenesis assessed with Johnsen score, seminiferous tubule integrity and apoptotic activity assessed with the expression of cleaved caspase 3 activity. A total of 36 male Wistar rats (6-week-old) were divided into six groups (n=6 for each group); (C) control group, S (sham group), V (varicocele-only group), V+M (varicocele + metformin group), V/E (varicocele + varicocelectomy group), V/E+M (varicocele + varicocelectomy + metformin group).

Suggested Citation

  • Erkan Erdem & Nazli Ece Güngör-Ordueri & Akin Usta & Cenk Kığ & Meric Karacan, 2019. "Metformin Reduces the Extent of Varicocele-Induced Damage in Testicular Tissue," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 6(4), pages 70-762:6, February.
    • Handle: RePEc:adp:jgjorm:v:6:y:2019:i:4:p:70-76
    DOI: 10.19080/GJORM.2019.06.555691
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