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Use of MicroRNA as the Therapeutic Targets for Treatment of Major Depressive Disorder

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  • Ashim Kumar Basak
  • Tridip chatterjee

Abstract

Major depressive disorder is a global disease burden. It is major psychiatric disorder in which the patients suffer from the serious dysfunctions of the cognitive system and deprivation of mood, anhedonia etc. Stress is the major contributory factor of the of depression and a large number of depression patients become the victims of suicide. Depression is associated with a number of degenberative changes in the brain associated with cognitive functions and mood. Current therapies of depression aim to restore the cognitive functions of the patient by promoting neurogenesis in their brain. However, all these types of therapies have many limitations which provoke us to develop a more efficient therapy for the treatment of major depression. In recent time, the uses of microRNAs in the treament of many diseases have got popularities. In this present review we have discussed the possible advantages of using miRNA as the therapeutic target of major depression.

Suggested Citation

  • Ashim Kumar Basak & Tridip chatterjee, 2017. "Use of MicroRNA as the Therapeutic Targets for Treatment of Major Depressive Disorder," Global Journal of Intellectual & Developmental Disabilities, Juniper Publishers Inc., vol. 3(5), pages 121-126, December.
    • Handle: RePEc:adp:jgjidd:v:3:y:2017:i:5:p:121-126
    DOI: 10.19080/GJIDD.2017.03.555622
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    1. Priti Kumar & Haoquan Wu & Jodi L. McBride & Kyeong-Eun Jung & Moon Hee Kim & Beverly L. Davidson & Sang Kyung Lee & Premlata Shankar & N. Manjunath, 2007. "Transvascular delivery of small interfering RNA to the central nervous system," Nature, Nature, vol. 448(7149), pages 39-43, July.
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