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Congenital Toxoplasmosis: Time for a New Treatment Approach

Author

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  • Sam D Chorlton

    (Department of Pathology and Laboratory Medicine, University of British Columbia, Canada)

Abstract

Congenital toxoplasmosis is caused by in utero infection of the fetus with the intracellular parasite Toxoplasma gondii. Upon infection, the parasite forms life-long cysts in fetal brain which are resistant to the currently accepted therapy of pyrimethamine and sulfadiazine. These cysts commonly reactivate later in life causing visual impairment through choriretinitis, and less frequently neurological impairment such as hydrocephalus, cortical atrophy, seizures and encephalopathy. New therapies have the potential to alleviate a significant burden of disease by reducing cyst burden in neonatal brain. Atovaquone is perhaps the most promising drug given its low side-effect profile, established safety and efficacy in animal models. Randomized trials are needed to evaluate it and other potential drugs as adjunctive treatment in congenital toxoplasmosis.

Suggested Citation

  • Sam D Chorlton, 2017. "Congenital Toxoplasmosis: Time for a New Treatment Approach," Global Journal of Intellectual & Developmental Disabilities, Juniper Publishers Inc., vol. 2(1), pages 8-10, August.
    • Handle: RePEc:adp:jgjidd:v:2:y:2017:i:1:p:8-10
    DOI: 10.19080/GJIDD.2017.02.555579
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