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Targeting Cancer Signaling Pathways by Nimbolide A review on Chemoprevention and Therapeutic Studies

Author

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  • Mohd Owais Ansari
  • GGHA Shadab
  • Hifzur R Siddique

    (Department of Zoology, Aligarh Muslim University, India)

Abstract

Neem (Azadirachta indica), has been in use as a traditional medicine since ancient time. Nimbolide, a phytochemical from neem has attracted the cancer scientists as a potential natural molecule for the effective cancer prevention and therapy. The researchers also highlight the efficiency and efficacy of nimbolide in different experimental systems. Moreover, nimbolide does not have the side effects in vivo model systems. The importance of nimbolide in cancer prevention and therapy is very high because nimbolide targets multiple signaling pathways which are involve in cell proliferation, cell cycle, apoptosis, invasion, metastasis and angiogenesis. However, more experimental proofs are needed to validate nimbolide application in cancer prevention and therapy. In this mini-review, we discuss different recent findings to target signaling molecules in different preclinical cancer. the important discoveries related to nimbolide against different preclinical cancer models. We also discuss the possibilities to use nimbolide as preventive and therapeutic molecule against the dreaded disease cancer.

Suggested Citation

  • Mohd Owais Ansari & GGHA Shadab & Hifzur R Siddique, 2017. "Targeting Cancer Signaling Pathways by Nimbolide A review on Chemoprevention and Therapeutic Studies," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 8(4), pages 66-70, December.
    • Handle: RePEc:adp:jctoij:v:8:y:2017:i:4:p:66-70
    DOI: 10.19080/CTOIJ.2017.08.555741
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