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Retinoic Acid Binding Proteins and Cancer: Similarity or Polarity?

Author

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  • Elena M Tchevkina

    (Institute of Carcinogenesis, NN Blokhin National Medical Research Center of Oncology, Russia)

Abstract

Vitamin A is a precursor for the multiple active metabolites, known as retinoids, among which retinoic acid (RA) is one of the most essential for the embryonic development as well as for the tissue maintenance and renewal in adults. RA upregulates the transcription factors that control the expression of a huge number of genes regulating differentiation, proliferation, cellular death and survival. Potent anticarcinogenic activity of RA has been repeatedly shown for several types of cancer cells. However, the implementation of RA as a therapeutic agent for cancer treatment is limited by the rapid acquisition of RA resistance. Moreover, in some type of tumors RA promotes rather than inhibits cell malignancy. One of the reasons for the development of RA resistance and such distinct functional significance of RA in carcinogenesis is attributed to the proteins, responsible for the delivery of RA to its nuclear receptors regulating transcription and intracellular signaling. The association with the different kind of RA binding proteins largely determines the future fate of RA and its intracellular activity.

Suggested Citation

  • Elena M Tchevkina, 2017. "Retinoic Acid Binding Proteins and Cancer: Similarity or Polarity?," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 8(2), pages 31-35, December.
    • Handle: RePEc:adp:jctoij:v:8:y:2017:i:2:p:31-35
    DOI: 10.19080/CTOIJ.2017.08.555733
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