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NK cell as a Novel Tool to Regulate and Inhibit the Progressive Growth of Tumor after Chemotherapy

Author

Listed:
  • Munendra Singh Tomar
  • Sanjay Kumar
  • Rishi Kant Singh
  • Praveen Kumar Verma
  • Surya Pratap Singh
  • Amit Kumar
  • Arbind Acharya

    (Department of Zoology, Banaras Hindu University, India)

  • Pramod Kumar Gautam

    (Department of Biochemistry, All India Institutes of Medical Sciences, India)

  • Sanjay Kumar

    (Department of Biological Sciences, Albama State University, USA)

Abstract

Natural killer Cells (NK cells) are a part of innate immune system that’s play an important role as cytotoxic lymphocytes. Two types of receptors, activating (AR) and inhibitory (IR) are found on NK cells. These receptors have their specific role in the regulation of NK cells for killing the tumor cells or virus infected cells by the stimulation and secretion of cytotoxic granules containing perforin and granzyme. The functions of NK cells are inhibited by regulatory T (Treg) cells through interacting with NK cell surface receptors but the functions of these Treg cells can be modulated by some chemotherapeutic drugs like cyclophosphamide (CYP), gemcitabine, prednisolone and many more. Moreover, CYP inhibits the functions of Treg cell through various factors along with depletion of Treg cells number. Inhibition of Treg cell functions increases the activity of NK cells through modulating the expression of ARs and IRs of NK cells. Critical observation of such chemotherapeutic drugs and the regulation of NK cells on the basis of their ARs and IRs expression can be a promising chemo-immunotherapeutic approach for the treatment of cancer.

Suggested Citation

  • Munendra Singh Tomar & Sanjay Kumar & Rishi Kant Singh & Praveen Kumar Verma & Surya Pratap Singh & Amit Kumar & Arbind Acharya & Pramod Kumar Gautam & Sanjay Kumar, 2017. "NK cell as a Novel Tool to Regulate and Inhibit the Progressive Growth of Tumor after Chemotherapy," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 8(1), pages 11-13, November.
    • Handle: RePEc:adp:jctoij:v:8:y:2017:i:1:p:11-13
    DOI: 10.19080/CTOIJ.2017.08.555728
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