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Mast Cell Infiltration and Leukotriene Receptor Expression in Colorectal Adenoma: Preventive Application of Malignant Transformation Based on Common Pathological Findings

Author

Listed:
  • Masao Sugamata
  • Tomomi Ihara
  • Miho Sugamata

    (Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan)

  • Yasunari Mano

    (Department of Clinical Drug Informatics, Tokyo University of Science, Japan)

  • Ken Takeda

    (Department of Hygiene Chemistry, Tokyo University of Science Sanyo Onoda Yamaguchi, Japan)

Abstract

The prevention of the malignant tumor is thought to be early detection, because the mechanism that tumor cells result, and progresses has not been yet made clear. We have already identified leukotriene receptor expression and mast cells infiltration; these are common pathologic findings in various malignant tumors. In this time, we detected a similar common pathologic finding for polyp of colon suggestive of the precancerous change in the purpose of preventing malignant tumor and examined a malignant transformation risk and the association of these findings. Thirty samples of colorectal adenoma (colonic polyp) tissues obtained from patients with high-grade dysplasia (n=15) or low-grade dysplasia (n=15). These samples were observed mast cells and detected of leukotriene receptors under a light microscope, and were compared using statistical analysis. Mast cells infiltration and the expression of leukotriene receptor were common in the colonic polyp tissues and, similar to malignant tumors, were found.

Suggested Citation

  • Masao Sugamata & Tomomi Ihara & Miho Sugamata & Yasunari Mano & Ken Takeda, 2017. "Mast Cell Infiltration and Leukotriene Receptor Expression in Colorectal Adenoma: Preventive Application of Malignant Transformation Based on Common Pathological Findings," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 7(4), pages 56-60, October.
    • Handle: RePEc:adp:jctoij:v:7:y:2017:i:4:p:56-60
    DOI: 10.19080/CTOIJ.2017.07.555718
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