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T-Cell Large Granular Lymphocytic Chronic Leukemia: Treatment Experience with Cyclosporine

Author

Listed:
  • Ilie Alina

    (Hematology Department, Emergency Municipal Hospital Timisoara, Romania)

  • Guran Catalina
  • Oros Dacian Nicolae
  • Calamar Popovici Despina
  • Ionita Ioana

    (Department of Internal Medicine 1 – Hematology, “Victor Babes†University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania)

Abstract

The patient presented herself at the hospital in June 2018 with severe anemia (Hgb= 5,4g/dl), mild leucopenia (Le= 3980/mm³) and grade III neutropenia (Ne=557/mm³). She underwent bone marrow biopsy and flow cytometry which established the diagnosis of Large Granular T-cell Leukemia. She was given treatment with Ciclosporine 50mg 6cps/day, which was reduced at 3 cps/day because the patient developed pancytopenia at 6cps/day. The blood count test after 6 months of treatment was greatly improved: she obtained normal levels of hemoglobin and platelets, with the persistence of asymptomatic neutropenia. At the one-year follow-up we had an adequate response, but at the 18 months follow-up she has developed mild pancytopenia, which leads us to believe that she is relapsing under the Ciclosporine treatment.

Suggested Citation

  • Ilie Alina & Guran Catalina & Oros Dacian Nicolae & Calamar Popovici Despina & Ionita Ioana, 2020. "T-Cell Large Granular Lymphocytic Chronic Leukemia: Treatment Experience with Cyclosporine," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 16(4), pages 68-70, July.
    • Handle: RePEc:adp:jctoij:v:16:y:2020:i:4:p:68-70
    DOI: 10.19080/CTOIJ.2020.16.555943
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