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Awareness of Emerging Novel Epigenetic Targeting Therapy in Acute Myeloid Leukemia

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  • Nahla AM Hamed

    (Hematology Department, Alexandria University, Egypt)

Abstract

Many of the recurrently mutated genes in AML may affect epigenetic regulators of transcription. Epigenetic modifiers represent a major focus of interest and are highlighted as attractive targets for personalized therapy in AML. Some novel agents showed encouraging clinical activity in early phase trials while other agents (e.g., EZH2 inhibitors) are in early preclinical development and will likely be tested in AML trials in the near future. Many novel agents in development target niche areas for AML leukemogenesis including the epigenetic regulators BET proteins, DOT1L, and LSD1 which are suggested to have a role in MLL-r AML and possibly other subsets.

Suggested Citation

  • Nahla AM Hamed, 2018. "Awareness of Emerging Novel Epigenetic Targeting Therapy in Acute Myeloid Leukemia," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 11(3), pages 86-88, July.
    • Handle: RePEc:adp:jctoij:v:11:y:2018:i:3:p:86-88
    DOI: 10.19080/CTOIJ.2018.11.555815
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