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A Review on Hepatitis B Virus and Hepatocellular Carcinoma

Author

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  • Obeagu Emmanuel Ifeanyi

    (Department of University Health Services, Michael Okpara University of Agriculture, Nigeria)

Abstract

Hepatitis B virus is a member of the hepadna virus family, the virus particle consist of outer lipid envelop and an icosahendral nucleocapisd core composed of protein. The nucleus capsid encloses the viral DNA and a DNA polymerase that as reverse transcriptase activity. The genome of hepatitis B virus is made up of circular DNA, but it is unusual because the DNA is not fully double stranded. Transmission of hepatitis B virus results from exposure to infectious blood or body fluids containing blood. Chronic infection with hepatitis B virus may be either a symptomatic or may be associated with chronic inflammation of the liver, leading to cirrhosis which dramatically increases the incidence of hepatocellular carcinoma. It has been irrefutably shown that chronic HEPATITIS B VIRUS infection can lead to hepatocellualr carcinoma (HCC). The most common features of HCC include; abdominal pain, upper abdominal mass, ascites, oedema of the lower extremities, haematemesis, melana and fever, jaundice is a relatively uncommon compliant.

Suggested Citation

  • Obeagu Emmanuel Ifeanyi, 2018. "A Review on Hepatitis B Virus and Hepatocellular Carcinoma," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 10(2), pages 26-31, April.
    • Handle: RePEc:adp:jctoij:v:10:y:2018:i:2:p:26-31
    DOI: 10.19080/CTOIJ.2018.10.555784
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