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Aptamers: Update to Lateral Flow Immunoassays

Author

Listed:
  • Gurdyal Singh
  • Vikas Pahal

    (Department of Microbiology, Dolphin (PG) College of Life Sciences, Punjabi University, India)

Abstract

A key driver for treatment of a disease is the time to obtain the test result. Lateral flow immunoassays are multifaceted and available for a broad range of analytes from blood proteins, mycotoxins, viral pathogens or bacterial toxins. The other key advantage of these rapid tests as compared to other immunoassays is the simplicity of the test with requirement of little sample or reagent preparation. Lateral flow assay requires assembly of a number of variants such as formats, biorecognition molecules, labels, detection systems and applications. This manuscript provides a brief overview of use of aptamers in lateral flow assay without using whole antigens or antibodies for the targets. Due to a number of important potential performance advantages, aptamers are receiving increasing attention in lateral flow applications. The identification of specific nucleic acids (aptamers) which bind to a wide range of target molecules with high affinity and specificity is done by in vitro selection of combinatorial libraries of RNA or DNA. These are used as new biological recognition molecules in lateral flow immunoassays assuring progress for fast and easy detection of antigens/antibodies.

Suggested Citation

  • Gurdyal Singh & Vikas Pahal, 2017. "Aptamers: Update to Lateral Flow Immunoassays," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 9(5), pages 93-94, October.
    • Handle: RePEc:adp:jctbeb:v:9:y:2017:i:5:p:93-94
    DOI: 10.19080/CTBEB.2017.09.555773
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