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Poly Comb Group Proteins A Dual Player in Ageing and Cancer

Author

Listed:
  • M Krishnaveni

    (Department of Biochemistry, Periyar University, India)

Abstract

Maintenance of health at middle age is more important to have a longer disease free life. Every human stem cells are exposed continuously to several genotoxic stimuli from younger age, which are repaired by DNA repair process using DNA polymerase δ1, at some point during ageing, the ability to repair the damage was exhausted followed by instability in genome, causing cancer in elderly. This confirms the association of longevity to repair process.

Suggested Citation

  • M Krishnaveni, 2017. "Poly Comb Group Proteins A Dual Player in Ageing and Cancer," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 9(5), pages 90-92, October.
  • Handle: RePEc:adp:jctbeb:v:9:y:2017:i:5:p:90-92
    DOI: 10.19080/CTBEB.2017.09.555772
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    References listed on IDEAS

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    1. Jacqueline J. L. Jacobs & Karin Kieboom & Silvia Marino & Ronald A DePinho & Maarten van Lohuizen, 1999. "The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus," Nature, Nature, vol. 397(6715), pages 164-168, January.
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