IDEAS home Printed from https://ideas.repec.org/a/adp/jctbeb/v7y2017i1p13-20.html
   My bibliography  Save this article

Present Situation of Viral Vector Manufacturing and Ways to Overcome Potential Barriers in View of the Routine Large Scale Production and Use of Viral Vectors

Author

Listed:
  • O-W Merten

    (Généthon, France)

Abstract

The marketing authorization of two gene therapy treatments in Europe has opened the door to routine manufacturing of viral vectors, in particular, of MLV, LV, and AAV vectors, meaning that a quantum leap in routine manufacturing technology will be necessary in order to be able to produce the required quantities. However, this quantum leap is already required for producing the vector amounts necessary for performing advanced clinical trials, in particular, with respect to neuromuscular diseases (NMDs), such as Duchene Muscular Dystrophy (DMD). This review presents briefly the actual situation of the production of the most important viral vectors (AV, MLV, LV, and AAV) and barriers to be overcome in view of the large scale manufacturing of these vectors for routine use.

Suggested Citation

  • O-W Merten, 2017. "Present Situation of Viral Vector Manufacturing and Ways to Overcome Potential Barriers in View of the Routine Large Scale Production and Use of Viral Vectors," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 7(1), pages 13-20, August.
    • Handle: RePEc:adp:jctbeb:v:7:y:2017:i:1:p:13-20
    DOI: 10.19080/CTBEB.2017.07.555704
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/ctbeb/pdf/CTBEB.MS.ID.555704.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/ctbeb/CTBEB.MS.ID.555704.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/CTBEB.2017.07.555704?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:jctbeb:v:7:y:2017:i:1:p:13-20. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.