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Current and Future Applications for DNA Sequence for Forensics, Biosurveillance, Clinical Health and Detection

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  • John P Jakupciak

    (Cipher Systems, USA)

Abstract

Many DNA/RNA/protein analytical methods are currently available, ranging from the standard culturing methods, which are tedious, slow, and dependent on achieving culture of the agent, to simplistic single biomarker genomic based tests, to high resolution DNA sequencing, which for a few unique techniques, provide identification of metagenomics samples at the strain level. The latter are faster than culture but perform in a near real-time response window. Real-time PCR limited detection methods are restricted to multiplex identification of few bioagents and test results contain the potential of error due to innate amplification errors, coupled with the requirement to know in advance what the agent is in the sample prior to design primers (probes) for detection. Rapid direct sequencing, coupled with data base matching, offers the most reliable, effective, reproducible, and cost effective approach to biological detection at strain level with details to measure major and minor population content.

Suggested Citation

  • John P Jakupciak, 2017. "Current and Future Applications for DNA Sequence for Forensics, Biosurveillance, Clinical Health and Detection," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 1(3), pages 53-62, February.
    • Handle: RePEc:adp:jctbeb:v:1:y:2017:i:2:p:53-62
    DOI: 10.19080/CTBEB.2017.01.555561
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    References listed on IDEAS

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    1. John P Jakupciak, 2017. "Population Sequencing," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 2(3), pages 51-52, March.
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