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Development of Advanced-Laser Micro Dissection System for Protein Aggregation Diseases

Author

Listed:
  • Naomi Hachiya

    (Research and Development Department, Biotechnology Group, Tokyo Metropolitan Industrial Technology Research Institute, Japan)

  • Yoshimichi Kozuka

    (Shinku-Device Instrument, Japan)

Abstract

Results of the remarkable increase of life expectancy, the number of patients that have age-related diseases are increasing. Protein aggregation diseases are belonging to such diseases, and that submicron order of highly aggregated inclusions formed in tissues. Nowadays, effective therapeutic approaches are required, however, etiology of the diseases remain to be elucidated. One reason is that the size of inclusion is too small to purify without contamination especially in some disease cases thus we have difficulty in analyzing them biochemically. Therefore, it wouldn’t be surprise that we hardly get reliable results even when we use a highly sensitive mass spectrometry in research. To solve this problem, we have developed an improved laser microdissection system; (Advanced-LMD) consisted of a deep ultraviolet laser with 266 nm of wavelength and fluorescent microscopy. Advanced-LMD can isolate minute size of inclusions derived from tissues.

Suggested Citation

  • Naomi Hachiya & Yoshimichi Kozuka, 2018. "Development of Advanced-Laser Micro Dissection System for Protein Aggregation Diseases," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 12(4), pages 75-78, February.
    • Handle: RePEc:adp:jctbeb:v:12:y:2018:i:4:p:75-78
    DOI: 10.19080/CTBEB.2018.12.555841
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